The regioselective C5 halogenation of quinolines using sodium halides under transition metal-free conditions |
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Authors: | Jun-Ying Jiao Yuan-Jun Mao An-Wei Feng Xiao-Fang Li Meng-Ting Li Xiao-Hong Zhang |
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Affiliation: | College of Chemical and Materials Engineering, Wenzhou University, Wenzhou 325035, China |
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Abstract: | An efficient and mild halogenation of 8-acylaminoquinoline at the C5 position was described. The reaction utilized easily available sodium halides as the halogen sources and proceeded smoothly under transition metal-free conditions. Various 8-aminoquinolines with a number of functional groups were compatible in this reaction to afford the corresponding halogenated products in moderate to good yields. Moreover, the reaction conditions also tolerated the substrates without the 8-aminoquinolyl auxiliary, such as N-phenyl amide and N-naphthyl amide. |
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Keywords: | Halogenation Quinolines Sodium halides |
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