Site-selective Csp3-H aryloxylation of natural product Tanshinone IIA and its analogues |
| |
| Authors: | Bing Liang Shujuan Yu Jie Li Fan Wang Gaolin Liang Ao Zhang Chunyong Ding |
| |
| Institution: | 1. Nano Science and Technology Institute, University of Science and Technology of China, Suzhou 215123, China;2. ShanghaiTech University, Shanghai 20120, China;3. CAS Key Laboratory of Receptor Research, Synthetic Organic & Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;4. University of Chinese Academy of Sciences, Beijing 100049, China |
| |
| Abstract: | A novel catalyst-free Csp3-H aryloxylation approach allowing for rapid installation of a wide range of aryloxyl groups regioselectively at the C-4 position of Tanshinone IIA under simple and mild conditions was developed. This unique protocol exhibited atom-/step-economy, low cost, high efficiency and robust functional-group tolerance, which will greatly facilitate to diversify the A-ring of the bioactive natural product. |
| |
| Keywords: | Natural product Tanshinone IIA Chemical modification Aryloxylation C-H activation |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
