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Synthesis of chiral hydantoin derivatives by homogeneous Pd-catalyzed asymmetric hydrogenation
Authors:Bao-De Ma  Sheng-Hua Du  Yu Wang  Xiao-Ming Ou  Ming-Zhi Huang  Li-Xin Wang  Xiao-Guang Wang
Institution:1. State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China;2. National Engineering Research Centre for Agrochemicals, Hunan Haili Chemical Industry Co., Ltd, Changsha 410007, China
Abstract:5-Aryl substituted chiral hydantoin derivatives were synthesized via asymmetric hydrogenation of prochiral exocyclic alkenes using a Pd/BINAP catalyst. Moderate to good enantioselectivity were obtained (21–90% ee). A chiral Brönsted acid additive was found to be a key factor to obtain high enantioselectivity.
Keywords:Corresponding authors  
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