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Synthesis of chiral hydantoin derivatives by homogeneous Pd-catalyzed asymmetric hydrogenation |
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| Authors: | Bao-De Ma Sheng-Hua Du Yu Wang Xiao-Ming Ou Ming-Zhi Huang Li-Xin Wang Xiao-Guang Wang |
| Institution: | 1. State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China;2. National Engineering Research Centre for Agrochemicals, Hunan Haili Chemical Industry Co., Ltd, Changsha 410007, China |
| Abstract: | 5-Aryl substituted chiral hydantoin derivatives were synthesized via asymmetric hydrogenation of prochiral exocyclic alkenes using a Pd/BINAP catalyst. Moderate to good enantioselectivity were obtained (21–90% ee). A chiral Brönsted acid additive was found to be a key factor to obtain high enantioselectivity. |
| Keywords: | Corresponding authors |
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