TEMPO-catalyzed oxidative dimerization and cyanation of indoles for the synthesis of 2-(1H-indol-3-yl)-3-oxoindoline-2-carbonitriles |
| |
| Authors: | Lili Jiang Xiangjun Peng Panpan Huang Zhengwang Chen Liangxian Liu |
| |
| Affiliation: | 1. Department of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou, Jiangxi 341000, PR China;2. School of Pharmaceutical Science, Gannan Medical University, Ganzhou, Jiangxi 341000, PR China |
| |
| Abstract: | A method for the combinative oxidative homo dimerization and cyanation of free indole derivatives catalysed by TEMPO along with silver carbonate was demonstrated for the first time This new methodology is both atom and step efficient and is applicable to a broad scope of substrates, allowing the synthesis of a range of synthetically valuable 2-(1H-indol-3-yl)-3-oxoindoline- 2-carbonitriles in moderate to excellent yields. Furthermore, selected compounds 6b and 6g exhibit moderate to good anti-schistosomicidal activities. |
| |
| Keywords: | Indole Bisindole TEMPO Cyanation |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
