Synthesis of fluorine-substituted [2.2]paracyclophane-based carbene precursors for copper-catalyzed enantioselective boration of α,β-unsaturated ketones |
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Authors: | Linyong Wang Meng Ye Lei Wang Wenzeng Duan Chun Song Yudao Ma |
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Institution: | Department of Chemistry, Shandong University, Shanda South Road No. 27, Jinan 250100, People’s Republic of China |
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Abstract: | Fluorine-substituted 2.2]paracyclophane-based carbene precursors have been successfully synthesized and applied to copper-catalyzed asymmetric β-boration of α,β-unsaturated ketones. Fluorination of the planar chiral carbenes has a beneficial impact on the catalytic performance of the relevant complexes. A variety of chiral β-boryl ketones were obtained in excellent yields (up to 99%) and with high enantioselectivities (up to 99% ee). |
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Keywords: | Corresponding author Tel : +86 531 88361869 fax: +86 531 88364464 |
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