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Observation of a rectangular columnar phase in a DNA-calcium-zwitterionic lipid complex
Authors:McManus Jennifer J  Rädler Joachim O  Dawson Kenneth A
Affiliation:Department of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland.
Abstract:In the presence of calcium, DNA and unilamellar liposomes of the zwitterionic lipid DPPC form a complex in which DNA strands are embedded between a lamellar phase of DPPC. In some complexes, in-plane alignment of the DNA strands occurs, where a DNA-DNA interaxial distance can be measured using small-angle X-ray scattering. Here we report a higher level of DNA organization, with a rectangular columnar phase of DNA identified within this complex structure. This observation is important in view of recent interests in creating new synthetic systems at the interface of biology.
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