Formylation of pyrrolo-[1,2-<Emphasis Type="Italic">a</Emphasis>]pyrazines |
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Authors: | V I Terenin M A Butkevich A S Ivanov N A Tselischeva E V Kabanova |
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Institution: | (1) M. V. Lomonosov Moscow State University, Moscow, 119992, Russian |
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Abstract: | The formylation of pyrrolo1,2-a]pyrazines containing alkyl, aryl, or hetaryl substituents in positions 1 and 6 of the heterocycle
has been studied. It has been shown that formylation of 1-phenyl-and 1-(2 thienyl)pyrrolo1,2-a]pyrazine occurs selectively
at the α-position of the pyrrole ring. In all of the remaining examples the reaction course depends on substituent, reagent
ratio, and reaction time.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 88–93, January, 2008. |
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Keywords: | pyrrolo[1 2-a]pyrazine formylation electrophilic substitution Vilsmeier-Haack reaction |
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