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| L-赖氨酸长链烷基酯双DTPA酰胺钆(Ⅲ)配合物的合成、表征与弛豫效能 | |
| 引用本文： | 俞开潮,李留义,万福贤,周锦兰,丁尚武,叶朝辉.L-赖氨酸长链烷基酯双DTPA酰胺钆(Ⅲ)配合物的合成、表征与弛豫效能[J].光谱学与光谱分析,2006,26(4):670-673. |
| 作者姓名： | 俞开潮 李留义 万福贤 周锦兰 丁尚武 叶朝辉 |
| 作者单位： | 1. 华中科技大学化学系,湖北,武汉,430074;高雄中山大学化学系与纳米科技中心,高雄,80424 2. 华中科技大学化学系,湖北,武汉,430074 3. 高雄中山大学化学系与纳米科技中心,高雄,80424 4. 波谱与原子分子物理国家重点实验室,中国科学院武汉物理与数学研究所,湖北,武汉,430071 |
| 基金项目： | 中国科学院资助项目 , 国家重点实验室基金 |
| 摘 要： | 通过二乙三胺五乙酸单环酸酐(DTPA-MA)分别与L-赖氨酸的十八酯、十六酯、十四酯和十二酯的双酰化反应, 制得四种含有双DTPA螯合单元的新型配体. 它们与GdCl3·6H2O配合得到相应的双核钆(Ⅲ)配合物. 表征了配体和配合物的结构, 测试了配合物的纵向弛豫效能(R1). 结果表明: 这四种新钆配合物的R1都高于Gd-DTPA. |
| 关 键 词： | 磁共振成像 二倍体造影剂 L-赖氨酸酯 两亲性 Gd-(Ⅲ)配合物 弛豫效能(R1) |
| 文章编号： | 1000-0593（2006）04-0670-04 |
| 收稿时间： | 2005-02-18 |
| 修稿时间： | 2005-06-10 |
Synthesis,Characterization and Relaxivity of Dimeric DTPA-Gadonium(Ⅲ) Complexes with Long Chain Alkyl Esters of L-Lysine |
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| YU Kai-chao,LI Liu-yi,WAN Fu-xian,ZHOU Jin-lan,DING Shang-wu,YE Chao-hui.Synthesis,Characterization and Relaxivity of Dimeric DTPA-Gadonium(Ⅲ) Complexes with Long Chain Alkyl Esters of L-Lysine[J].Spectroscopy and Spectral Analysis,2006,26(4):670-673. | |
| Authors: | YU Kai-chao LI Liu-yi WAN Fu-xian ZHOU Jin-lan DING Shang-wu YE Chao-hui |
| Institution: | Department of Chemistry, Huazhong University of Science and Technology, Wuhan, China. |
| Abstract: | To look for new MRI (magnetic resonance imaging) contrast agents with higher relaxivity as well as liver-selecsivity, four novel ester-amino ligands were synthesized by bis-acylation of octadecanyl, hexadecanyl, tetradecanyl and dedecanyl L-lysine with diethylenetriaminepentaacetic acid mono-anhydride (DTPA-MA), respectively. The corresponding dimeric Gd(III) complexes were gained by the reaction of these ligands with GdCl3 x 6H2O. All ligands and complexes were characterized by FTIR, 1H NMR and elemental analysis. The longitudinal relaxation time (T1) was measured, and relevant longitudinal relaxivity (R1) of these neatral binuclear Gd(III) complexes is: 6.48, 6.02, 5.76 and 5.68 L x mmol(-1) x s(-1), respectively, and all are higher than that of Gd-DTPA (4.98 L x mmol(-1) x s(-1)) (300 MHz). |
| Keywords: | MRI Dimeric contrast agent Ester of L-lysine Amphiphilicity Gadolinium complex Longitudinal relaxivity(R_1) |
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