| 萃取分光光度法测定盐酸洛美沙星 |
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| 引用本文： | 谭峰,郎惠云,李媛. 萃取分光光度法测定盐酸洛美沙星[J]. 分析化学, 2001, 29(5): 561-564 |
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| 作者姓名： | 谭峰 郎惠云 李媛 |
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| 作者单位： | 西北大学化学系, |
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| 摘 要： | 提出了测定盐酸洛美沙星 (LMX)的萃取分光光度法 ,该法基于在弱酸性条件下 ,盐酸洛美沙星与溴甲酚绿 (BMG)反应生成可被三氯甲烷萃取的离子对缔合物 ,其最大吸收波长为 415nm。药物浓度在 1～ 15mg/L(r=0 .9997)范围内符合比耳定律。表观摩尔吸收系数ε =2 .5× 10 4 L·mol-1·cm-1。最低检出限为 0 .0 14mg/L。回收率为 98.9%～ 10 1.6 %。该法可成功的用于药物制剂中洛美沙星含量的测定
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| 关 键 词： | 萃取分光光度法 盐酸洛美沙星 离子对缔合 抗菌素 药物分析 |
Extraction-Spectrophotometric Determination of Lomefloxacin |
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| Tan Feng,Lang Huiyun,Li Yuan. Extraction-Spectrophotometric Determination of Lomefloxacin[J]. Chinese Journal of Analytical Chemistry, 2001, 29(5): 561-564 |
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| Authors: | Tan Feng Lang Huiyun Li Yuan |
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| Abstract: | Extraction-spectrophotometric method for determination of lomefloxacin is proposed.The ion pairs complex of lomefloxacin with brornocresol green (BMG) can be extracted into CHCI3 at pH 3.6 and has absorption maximum at 415nm.The calibrationgraphs generated was linear over the range of 1～15mg/L drug in solution (r=0.9997).ε=2.5×104L·mol-1·cm-1.The detection limit is 0.014mg/L.The recovery of method is 98.9%～101.6%.The proposed method has been successfully applied to the determination of lomefloxacin in pharmaceutical formulations. |
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| Keywords: | Extraction spectrophotometric method lomefloxacin hydrochloride ionic associate |
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