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Dispersion of stratum corneum in an aqueous mixed solution of surfactants: the effect of a mixture of sodium dodecyl sulfate and N,N-dimethyldodecylamine oxide |
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| Authors: | K Takahashi M Hosaka Y Hanabusa E Ogawa N Suzuki S Hayashi E Yamada M Takahashi S Fukushima H Kamoda M Ueno |
| Institution: | a Department of Applied Chemistry, Faculty of Science, Science University of Tokyo, Kagurazaka 1-3, Shinjuku-ku, Tokyo 162, Japan b Institute for Advanced Skin Research Inc., Science University of Tokyo, Kagurazaka 1-3, Shinjuku-ku, Tokyo 162, Japan c Institute of Colloid and Surface Chemistry, Science University of Tokyo, Kagurazaka 1-3, Shinjuku-ku, Tokyo 162, Japan |
| Abstract: | Molecular interactions between sodium dodecyl sulfate (SDS) and N,N-dimethyldodecylamine oxide (C12DMAO), whose mixtures were effective for dispersion of stratum corneum (SC) into intact corneocytes, were studied and found to be strongest at an SDS/C12DMAO molar ratio of 1/3, when dispersion of SC was most effective and the sizes of the mixed micelles were largest. This dispersion effect was confirmed as being caused by the stronger solubilizing power of molecular complexes formed between SDS and C12DMAO in the binary mixed solutions by using 1H NMR. The mechanisms for removing intercellular lipids such as ceramides, cholesterol and their derivatives, which play an important role as adhesives among the corneocytes, and for dispersing SC into intact cells were proposed on the basis of supporting data obtained from 1H-NMR and light scattering measurements. |
| Keywords: | Correlation time N N-Dimethyldodecylamine oxide Hydrodynamic radius Sodium dodecyl sulfate Stratum corneum |
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