| 含VE微胶囊的制备及其控制释放性能研究 |
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| 引用本文： | 包德才,张琼钢,刘袖洞,马小军,袁权. 含VE微胶囊的制备及其控制释放性能研究[J]. 物理化学学报, 2004, 20(2): 178-181. DOI: 10.3866/PKU.WHXB20040214 |
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| 作者姓名： | 包德才 张琼钢 刘袖洞 马小军 袁权 |
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| 作者单位： | Laboratory of Biomedical Material Engineering, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023; School of Science of Chemistry and Food, Bohai University, Jinzhou 121000 |
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| 基金项目： | 国家自然科学基金(20176056)资助项目~~ |
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| 摘 要： | 以天然维生素E（VE）为芯材，利用Shirasu porous glass (SPG) 膜乳化结合液中干燥法，制备了粒径单分散的聚苯乙烯（PS）微胶囊.微胶囊的粒径为膜孔径的4倍，粒径单分散系数CV小于0.2.考察了改变PS和VE的比例及微胶囊的粒径对控制释放性能的影响.
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| 关 键 词： | 膜乳化 液中干燥法 维生素E 微胶囊 控制释放 |
| 收稿时间： | 2003-08-04 |
| 修稿时间： | 2003-08-04 |
Preparation of VE Microcapsules and Its Controlled Release Characteristics |
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| Bao De-Cai , Zhang Qiong-Gang Liu Xiu-Dong Ma Xiao-Jun Yuan Quan. Preparation of VE Microcapsules and Its Controlled Release Characteristics[J]. Acta Physico-Chimica Sinica, 2004, 20(2): 178-181. DOI: 10.3866/PKU.WHXB20040214 |
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| Authors: | Bao De-Cai Zhang Qiong-Gang Liu Xiu-Dong Ma Xiao-Jun Yuan Quan |
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| Affiliation: | Laboratory of Biomedical Material Engineering, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023; School of Science of Chemistry and Food, Bohai University, Jinzhou 121000 |
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| Abstract: | Monodisperse polystyrene(PS) microcapsules containing vitamin E(VE)were prepared by membrane emulsification-dying in liquid technique. The diameter of microcapsules was about 4 times the size of the pore diameter of Shirasu porous glass (SPG) membrane, and the coefficient of variation (CV) of the microcapsule size was less than 0.2, showing a good monodispersity. Furthermore, the effects of the ratio of PS to VE (m/m) and the diameter of microcapsules on the release characteristics were investigated. When the ratio of PS to VE (m/m) is 40/1, the permeability coefficients were 0.71×10－9 and 0.74×10－9 m•s－1 corresponding to the microcapsule diameters of 21.32 and 11.45 μm, and the concentrations of VE released were 8 and 12 mg•L－1 respectively, which conform to the optimal concentration in applications. |
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| Keywords: | Membrane emulsification Drying in liquid Vitamin E Microcapsule Co ntrolled release |
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