Modified Coumarins. 4. Synthesis and Biological Properties of Cyclopentaneannelated Furocoumarins |
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| Authors: | M. M. Garazd Ya. L. Garazd S. V. Shilin T. N. Panteleimonova V. P. Khilya |
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| Affiliation: | (1) Institute of Bioorganic and Petroleum Chemistry, National Academy of Sciences of the Ukraine, 02094 Kiev, ul. Murmanskaya, 1;(2) Taras Shevchenko Kiev National University, 01033, the Ukraine, Kiev, ul. Vladimirskaya, 64;(3) Institute of Gerontology, Academy of Medical Sciences of the Ukraine, 03114 Kiev, ul. yshgorodskaya, 67 |
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| Abstract: | Psoralen and allopsoralen analogs that contain an annelated cyclopentane were synthesized from 7-hydroxyand 9-hydroxy-1,2,3,4-tetrahydrocyclopenta[c]chromen-4-ones. 9-Phenyl-1,2,3,4-tetrahydrocyclopenta[c]furo[3,2-g]chromen-4-one exhibited low toxicity, acted as a CNS stimulant, and exhibited cardiotropic activity. |
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| Keywords: | coumarins furocoumarins psoralen allopsoralen 1,2,3,4-tetrahydrocyclopenta[c]chromen-4-one |
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