Potentiometric sensor for phenylephrine based on phenylephrine-tetraphenylborate lipophilic salt |
| |
Authors: | Adel F Shoukry Ragaa El-Sheikh Yousry M Issa Mohsen Zareh |
| |
Institution: | (1) Department of Chemistry, Faculty of Science, Cairo University, Cairo, Egypt;(2) Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt |
| |
Abstract: | Phenylephrine (PE) ion-selective electrode based on incorporation of phenylephrine-tetraphenylborate lipophilic salt in plasticized PVC matrices is constructed. The electrode shows near Nernstian response over the concentration range 1.5 × 10–4-10–1
M in solutions of pH 2.9–8.0 at 25°C. The electrode resists the effect of heat in the temperature range 25–55°C exhibiting an isothermal temperature coefficient of 0.0007 V/°C. The selectivity of the electrode for PE towards large number of inorganic cations, sugars and amino acids is investigated. Determination of PE in an eye-drops pharmaceutical preparation is carried out using the proposed electrode as potentiometric sensor. |
| |
Keywords: | phenylephrine ion-selective electrode poly(vinyl chloride) membrane drug analysis |
本文献已被 SpringerLink 等数据库收录! |