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Total synthesis of pyridovericin |
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| Authors: | Nageswara Rao Irlapati Aurelia Conte Rodolfo Marquez |
| Affiliation: | a Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK b Department of Chemistry, University of Loughborough, Loughborough, Leicester 2LE11 3TU, UK c School of Life Sciences, University of Dundee, Dundee DD1 4HN, UK |
| Abstract: | The total synthesis of the naturally occurring kinase inhibitor pyridovericin 1 is reported. A flexible and efficient synthesis has been accomplished in good yield from readily available 2,4-dihydroxypyridine. Pyridovericin is a key intermediate in our proposed biomimetic synthesis of pyridomacrolidin 2. |
| Keywords: | Pyridovericin Pyridomacrolidin Suzuki coupling Metal-halogen exchange |
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