Synthesis of new N-aryl oxindoles as intermediates for pharmacologically active compounds |
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| Authors: | Murat Acemoglu Thomas Allmendinger Jacques Cercus Gottfried H. Sedelmeier |
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| Affiliation: | a Chemical and Analytical Development, Novartis Pharma AG, CH-4002 Basel, Switzerland
b Chemical and Analytical Development, Novartis Institute for Biomedical Research, One Health Plaza, East Hanover, NJ 07936, USA |
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| Abstract: | Various new N-aryl oxindoles were synthesized as intermediates for the preparation of pharmacologically active 2-(N-arylamino)-phenylacetic acids. Two novel approaches were explored for the construction of diarylamine and N-aryl oxindole core structures, in addition to Buchwald-arylamination and Smiles rearrangement. Condensation of anilines with 2-oxo-cyclohexylidene-acetic acid derivatives and subsequent dehydrogenation is a new and viable method for the preparation of N-aryl oxindoles. |
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| Keywords: | Diarylamines N-Aryl oxyindoles 2-(N-Arylamino)-phenylacetic acids NSAID's |
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