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Diastereoselective Reformatsky reaction of methyl 4-bromocrotonate with 1,2:5,6-di-O-isopropylidene-α-d-ribo-hexofuranos-3-ulose: application to novel bicyclic nucleosides |
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| Authors: | Mukund K Gurjar Dandepally Srinivasa Reddy Mohan M Bhadbhade Rajesh G Gonnade |
| Institution: | National Chemical Laboratory, Pune 411 008, India |
| Abstract: | This paper describes an efficient synthetic route for novel bicyclic nucleosides. The stereochemistry of the targeted bicyclic nucleosides was successfully achieved by vinylogous Reformatsky reaction and ring closing metathesis reaction on a carbohydrate backbone. |
| Keywords: | Bicyclic nucleosides Vinylogous Reformatsky reaction Ring closing metathesis Grubbs' catalyst Vorbrü ggen-type coupling reaction |
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