A double alkylation—ring closing metathesis approach to spiroimines |
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Authors: | Margaret A Brimble Michael Trzoss |
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Affiliation: | Department of Chemistry, University of Auckland, Private Bag 92019, 23 Symonds St., Auckland, New Zealand |
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Abstract: | As part of a programme directed towards the synthesis of the marine toxins, the spirolides and gymnodimine, a convenient synthesis of the key bicyclic spiroimine ring systems has been developed. The method involves double alkylation of a simple lactam, Grubbs ring closing metathesis of the resultant dialkylated lactam then reduction of the lactam to an imine. |
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Keywords: | Gymnodimi Spirolactams β-Trimethylsilylethoxycarbonyl (TEOC) |
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