|
|||||
|
|
Parviflorenes B-F, novel cytotoxic unsymmetrical sesquiterpene-dimers with three backbone skeletons from Curcuma parviflora |
|
| Authors: | Kazufumi Toume Kentaro Yamaguchi Thaworn Kowithayakorn Kanki Komiyama |
| Affiliation: | a Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan b Chemical Analysis Center, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan c Temko Corporation, 4-27-4 Honcho, Nakano, Tokyo 164-0012, Japan d Department of Horticulture, Faculty of Agriculture, Khon Kaen University, Khon Kaen 40002, Thailand e The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan |
| Abstract: | Five novel natural products classified as dimeric sesquiterpenes, named parviflorenes B-F (2-6), possessing three types of novel backbone frameworks, have been isolated from Curcuma parviflora (Zingiberaceae). The structures of 2-6 were elucidated by means of spectroscopic studies, and the structure of 2 was further unambiguously established by X-ray crystallographic analysis. Compounds 2, 4, and 6 have an unsymmetrical bis-cadinane skeleton, while compound 3 is a dimer of cadinane and iso-cadinane, and compound 5 possesses another novel carbon framework consisting of two cadinanes with different bond-connection. These new compounds with novel carbon skeletons showed cytotoxicity against tumor cell lines. |
| Keywords: | Zingiberaceae Curcuma parviflora Dimeric sesquiterpene X-ray analysis Cytotoxicity |
| 本文献已被 ScienceDirect 等数据库收录！ | |