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Rapid oligosaccharide synthesis on a fluorous support |
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| Authors: | Kohtaro Goto Daisuke Hosaka Mamoru Mizuno Toshiyuki Inazu |
| Institution: | a The Noguchi Institute, Labolatry of Glycoorganic Chemistry, 1-8-1 Kaga, Itabashi-ku, Tokyo 173-0003, Japan b Department of Applied Chemistry, School of Engineering, and Institute of Glycotechnology, Tokai University, Kitakaname 1117, Hiratsuka, Kanagawa 259-1292, Japan |
| Abstract: | The novel fluorous support Hfb (hexakisfluorous chain-type butanoyl) was easily prepared. The Hfb group was readily introduced into the anomeric hydroxyl group of a carbohydrate, and was recyclable after cleavage. The use of the Hfb group was applicable for the rapid oligosaccharide synthesis in which the synthetic intermediates could be purified using fluorous and normal organic solvents. Each synthetic intermediate could be monitored by TLC, NMR and mass spectrometry. |
| Keywords: | Fluorous Glycosylation Oligosaccharide Synthetic method Support |
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