Jolkinolide D pharmacophore: synthesis and reaction with biomolecules |
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| Authors: | Akira Sakakura |
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| Affiliation: | Department of Chemistry, University of Tsukuba, Tsukuba, Ibaraki 305-8571, Japan |
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| Abstract: | To obtain information on the chemical modification of biomolecules with jolkinolide D, a bioactive diterpenoid of plant origin, jolkinolide D pharmacophore was synthesized, and its reactivity toward amino acids, nucleosides, and DNA was investigated. |
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| Keywords: | Jolkinolide D Pharmacophore Diterpenoid Synthesis Reactivity Alkylation |
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