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Development of β-hydroxyamide/titanium complexes for catalytic enantioselective silylcyanation of aldehydes |
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| Authors: | Biing-Jiun Uang I-Pin Fu Chyuan-Der Hwang Chun-Wei Chang Chun-Tzu Yang Der-Ren Hwang |
| Institution: | Department of Chemistry, National Tsing Hua University, Hsinchu 300, Taiwan, ROC |
| Abstract: | A highly enantioselective addition of trimethylsilylcyanide to aldehydes catalyzed by chiral titanium complexes is described. The chiral titanium complexes were prepared in situ from Ti(OiPr)4 and β-hydroxyamide ligands, that could easily be synthesized from ketopinic acid and C2 symmetrical chiral diamines in a small number of steps. |
| Keywords: | Cyanohydrin Asymmetric catalysis Titanium complex β-Hydroxyamide |
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