Structural studies of biarylpyridines fluorophores lead to the identification of promising long wavelength emitters for use in fluorescent chemosensors |
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Authors: | AG Fang |
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Institution: | Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0358, USA |
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Abstract: | Fluorescent chemosensors—molecules whose fluorescence emission changes in response to a reversible binding event—require both a substrate binding domain and a reporting fluorophore. Our approach to chemosensor development is based on a combination of a new signaling mechanism and a modular fluorophore synthesis. The latter feature has facilitated detailed study of the properties of polyarylpyridine fluorophores, and has led to the identification of a visibly-emissive pyridine as a promising lead structure for chemosensor development. The results of this study are described herein. |
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Keywords: | Fluorescence Chemosensor Pyridine Synthesis Spectroscopy |
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