Novel nicotinamide adenine dinucleotide analogues as selective inhibitors of NAD-dependent enzymes |
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| Authors: | Nathalie E Batoux Paul C Engel |
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| Affiliation: | a School of Chemistry, Queen's University, Belfast BT9 5AG, UK
b Department of Biochemistry, University College Dublin, Belfield, Dublin 4, Ireland |
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| Abstract: | Three novel dinucleotide analogues of nicotinamide adenine dinucleotide (NAD+) have been synthesised from d-ribonolactone. These compounds incorporate a thiophene moiety in place of nicotinamide and are hydrolytically stable. They have been evaluated as inhibitors of adenosine diphosphate ribosyl cyclase, glutamate dehydrogenase and Sir2 acyltransferase activities. Enzyme specificity and a high level of inhibition was observed for the dehydrogenase. |
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| Keywords: | C-nucleosides Dinucleotides NAD+ analogues |
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