Vilsmeier-Haack reactions of carbonyl compounds: synthesis of substituted pyrones and pyridines |
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| Authors: | Ajith Dain Thomas |
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| Institution: | School of Chemical Sciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam 686560, India |
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| Abstract: | Vilsmeier-Haack reaction of substituted phenylacetones leads to the formation of conjugated iminium salts which on aqueous basic work up afford 3-formyl-4-pyrones and on ammonium acetate-induced cyclization afford 5-aryl-4-chloronicotinaldehydes in good yields. |
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| Keywords: | Pyridines Pyrones Vilsmeier-Haack reagents Iminoalkylations Iminium salts Aryl acetones |
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