Interactions of acyclic and cyclic bis-phenanthridinium derivatives with ss- and ds-polynucleotides |
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Authors: | Ivo Piantanida,Predrag ?udi?,Hans-Jö rg Schneider |
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Affiliation: | a Laboratory for Supramolecular and Nucleoside Chemistry, Division of Chemistry and Biochemistry, Rudjer Boskovic Institute, Bijenicka 54, P.O.B. 1016, HR 10000 Zagreb, Croatia b FR Organische Chemie der Universität des Saarlandes, D 66041 Saarbrücken, Germany |
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Abstract: | The acyclic bis-phenanthridinium ligands 1, 2 and the cyclic analogue 3 bind to ss-RNA by bis-intercalation. Due to it's shorter linker 1 exhibits mono-intercalative binding to ds-polynucleotides, while a mixed mode of binding with 2 is shown to strongly dependent on the base composition and tertiary structure of ds-DNA and RNA. The cyclic analogue 3 binds to ds-polynucleotides by non-intercalative mode. Comparing the ss-/ds-polynucleotide selectivity obtained for 3 and previously reported for 3,8-linked bis-phenanthridinium analogues, it is clear that the more rigid structure and sterically more restricted cleft of the latter could better distinguish ss- from ds-polynucleotide regions. |
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Keywords: | Bis-phenanthridinium Intercalation DNA RNA |
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