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Rapid palladium-catalyzed aminations of aryl chlorides with aliphatic amines under temperature-controlled microwave heating |
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| Authors: | Bert U.W. Maes Kristof T.J. Loones Gaston Diels |
| Affiliation: | a Department of Chemistry, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp, Belgium b Janssen Pharmaceutica, Johnson and Johnson Pharmaceutical Research and Development, Turnhoutseweg 30, B-2340 Beerse, Belgium |
| Abstract: | Rapid Buchwald-Hartwig amination of electron neutral and rich aryl chlorides and bromides have been achieved using temperature-controlled microwave heating. Primary and secondary aliphatic amines can be coupled with these substrates in good yields within a reaction time of only 10 min. |
| Keywords: | Palladium Homogeneous catalysis Buchwald-Hartwig amination Aryl chlorides Aryl bromides Microwave irradiation |
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