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A practical and highly efficient synthesis of lennoxamine and related isoindolobenzazepines |
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| Authors: | Poolsak Sahakitpichan |
| Affiliation: | a Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, Vipavadee Rangsit Highway, Bangkok 10210, Thailand b Department of Chemistry, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand c Chulabhorn Research Centre, Institute of Science and Technology for Research and Development, Mahidol University, Salaya Campus, Bangkok, Thailand |
| Abstract: | Lennoxamine and related isoindolobenzazepines were prepared in high yield by intramolecular condensation of aldehyde isoindolones under basic conditions followed by catalytic hydrogenation of the resulting dehydroisoindolobenzazepines. |
| Keywords: | Lennoxamine Isoindolobenzazepine alkaloids |
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