Synthesis of novel hydropyrazolopyridine derivatives in solvent-free conditions via benzotriazole methodology |
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| Authors: | Rodrigo Abonia Emerson Rengifo Braulio Insuasty Manuel Nogueras |
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| Institution: | a Grupo de Investigación de Compuestos Heterocíclicos, Department of Chemistry, Universidad del Valle, A.A. 25360 Cali, Colombia
b Departamento de Química Inorgánica y Orgánica, Universidad de Jaén, 23071 Jaén, Spain |
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| Abstract: | The reaction between 5-N-(benzotriazol-1-ylmethyl)amino]-3-tert-butyl-1-phenylpyrazole or 5-amino-4-(benzotriazol-1-ylmethyl)-3-tert-butyl-1-phenylpyrazole with some unactivated and electron-rich alkenes has followed heterocyclization reactions to yield hydropyrazolopyridines, under solvent-free conditions, as predicted by benzotriazole methodology in contrast with those results obtained under solution. The reaction mechanism was proposed after fully spectroscopic analysis of final products and intermediates. |
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| Keywords: | 5-Aminopyrazole Hydropyrazolopyridines Benzotriazole Alkenes Cyclization Triaza-indacenes Triaza-cyclopentanaphthalenes |
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