A new approach to isoindoloisoquinolinones. A simple synthesis of nuevamine |
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| Authors: | Anne Moreau,Eric Deniau,Pierre Grandclaudon,Sté phane Lebrun |
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| Affiliation: | Laboratoire de Chimie Organique Physique, UMR 8009 “Chimie Organique et Macromoléculaire”, Bâtiment C3(2), Université des Sciences et Technologie de Lille, F-59655 Villeneuve d'Ascq Cédex, France |
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| Abstract: | A convenient and versatile short step synthesis of isoindoloisoquinolinones, illustrated by the total synthesis of the alkaloid nuevamine 1a, is described. The tetracyclic lactam compounds were obtained by a tactical combination of the Parham procedure for the elaboration of the isoindolinone template and an aryne-mediated cyclization giving rise to the nitrogen containing six-membered heteroring unit. |
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| Keywords: | Alkaloids Parham procedure Arynes Isoindolinones |
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