Lundurines A-D, cytotoxic indole alkaloids incorporating a cyclopropyl moiety from Kopsia tenuis and revision of the structures of tenuisines A-C |
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Authors: | Toh-Seok Kam Kuan-Hon Lim Masahiko Hayashi |
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Institution: | a Department of Chemistry, University of Malaya, Pantai Valley, 50603 Kuala Lumpur, Malaysia b The Kitasato Institute for Life Sciences and The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108, Japan |
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Abstract: | The leaf extract of the Borneo Kopsia, K. tenuis, provided several new indoles with a novel hexacyclic carbon skeleton, incorporating a cyclopropyl moiety. Two of these, displayed appreciable in vitro cytotoxicity against B16 melanoma cells, as well as the circumvention of drug-resistance in drug-resistant KB cells. The structures of tenuisines A-C were revised from a dimeric to a monomeric structure, based on new LSIMS data, and in conjunction with the preparation of the methyl iodide salt of tenuisine A. |
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Keywords: | Alkaloids NMR Plants |
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