Synthetic study of (+)-anthramycin using ring-closing enyne metathesis and cross-metathesis |
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| Authors: | Tsuyoshi Kitamura |
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| Affiliation: | Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan |
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| Abstract: | Synthesis of (+)-anthramycin was examined. A pyrrolobenzodiazepine skeleton could be synthesized by reductive cyclization of pyrrolidine derivative, which was obtained by enyne metathesis. The conjugated enamide ester part of (+)-anthramycin derivative was constructed by cross-metathesis. |
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| Keywords: | (+)-Anthramycin Pyrrolobenzodiazepine skeleton Deprotection |
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