Full and partial differentiation of tris-1,1,1-(hydroxymethyl)ethane via direct and indirect methodology |
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Authors: | Philip Clarke Sally Whiting |
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Institution: | School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, UK |
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Abstract: | Tris-1,1,1-(hydroxymethyl)ethane 1 was converted to a series of mono- and disubstituted derivatives. An indirect protocol for the differentiation of the alcohol groups was employed for the synthesis of partially and fully differentiated 1 containing a protected aldehyde unit. Complete differentiation of the alcohol groups was also achieved using a direct strategy (two steps from 1). The first synthesis of 1,3-dialdehydes derived from 1 is reported in two steps. |
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Keywords: | Scaffold Building block Alcohol differentiation Chemoselective acetal cleavage |
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