The asymmetric synthesis of (−)-pumiliotoxin C using tandem catalysis |
| |
| Authors: | Ewold W. Dijk Ben L. Feringa |
| |
| Affiliation: | Department of Organic and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands |
| |
| Abstract: | The potent neurotoxin (−)-pumiliotoxin C has been prepared in 8 steps starting from 2-cyclohexenone. Key steps are a tandem asymmetric conjugate addition-allylic substitution reaction and a tandem Heck-allylic substitution reaction. |
| |
| Keywords: | Alkaloids Heck-allylic substitution Pumiliotoxin C |
| 本文献已被 ScienceDirect 等数据库收录！ |
