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Tubiferal A, a backbone-rearranged triterpenoid lactone isolated from the myxomycete Tubifera dimorphotheca, possessing reversal of drug resistance activity |
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| Authors: | Kazuaki Kamata Hiroshi Hirota Masahiko Hayashi Masaaki Sato |
| Institution: | a Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263-8522, Japan b Genomic Sciences Center, RIKEN Yokohama Institute, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan c 1010-53 Ohtsu-ko, Kochi 781-5102, Japan d The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan |
| Abstract: | Tubiferal A, a novel rearranged triterpenoid lactone, has been isolated from field-collected fruit bodies of the myxomycete, Tubifera dimorphotheca, and its structure elucidated by spectral data. Tubiferal A (1) possesses a 9,10-secocycloartan-16,21-olide skeleton, and this new compound exhibited a reversal effect of vincristine (VCR) resistance (more than 4-fold) against VCR-resistant KB cell lines. Tubiferal B (2), corresponding to the seco acid of 1 was also isolated, but showed no comparable activity. |
| Keywords: | Myxomycete Tubifera dimorphotheca Rearranged triterpenoid Reveasal of drug resistance |
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