Polymeric salen-Ti(IV) or V(V) complex catalyzed asymmetric synthesis of O-acetylcyanohydrins from KCN, Ac2O and aldehydes |
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Authors: | Wei Huang Yuming Song Guoying Cao |
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Affiliation: | a Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023, People's Republic China b Graduate School of the Chinese Academy of Sciences, People's Republic China |
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Abstract: | Polymeric salen-Ti(IV) and V(V) complexes were employed in the enantioselective O-acetyl cyanation of aldehydes with potassium cyanide and acetic anhydride. The crosslinked polymeric salen-Ti(IV) catalyst exhibited good activities and enantioselectivities, up to 91% ee with 99% conversion was obtained at −20 °C with 1 mol% of catalyst (based on bimetallic catalytic unit). Moreover, six consecutive recyclings with the easily recovered crosslinked polymeric catalyst showed no obvious decrease in either activity or enantioselectivity. Linear polymeric salen-V(V) catalyst showed good catalytic efficiency too, up to 94% ee with 99% conversion was obtained at −42 °C with 5 mol% of catalyst. |
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Keywords: | O-Acetyl cyanohydrins Recyclable polymeric salen-Ti(IV) complexes Polymeric salen-V(V) complexes Potassium cyanide Aldehyde Asymmetric cyanation |
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