Enantioselective organocatalytic aldehyde-aldehyde cross-aldol couplings. The broad utility of α-thioacetal aldehydes |
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| Authors: | R Ian Storer |
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| Institution: | Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E California Blvd; Pasadena, CA 91125, USA |
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| Abstract: | An asymmetric proline catalyzed aldol reaction with α-thioacetal aldehydes has been developed. Thioacetal bearing aldehydes readily participate as electrophilic cross-aldol partners with a broad range of aldehyde and ketone donors. High levels of reaction efficiency as well as diastereo- and enantiocontrol are observed in the production of anti-aldol adducts. |
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| Keywords: | Aldol Catalysis Diastereoselection Enantioselective Organocatalysis Proline |
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