Synthesis and applications of chiral bis-THF in asymmetric synthesis |
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| Authors: | Alexandre Alexakis Axel Tomassini Stéphane Leconte |
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| Institution: | Department of Organic Chemistry, University of Geneva, 30 quai Ernest-Ansermet, 1211 Genève 4, Switzerland |
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| Abstract: | The synthesis of enantiopure bis-THF is described, starting from d-mannitol. Bis-THF is used as chiral ligand for organolithium reagents in four different reactions. The enantioselectivity provided by this ligand is moderate, and the asymmetric induction is in line with the expected model. |
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| Keywords: | Asymmetric synthesis Chirality Diether Organolithium reagents Coordination |
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