Alpha- and beta-polypeptides show a different stability of helical secondary structure |
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| Authors: | Thereza Soares |
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| Institution: | Laboratory of Physical Chemistry, Swiss Federal Institute of Technology Zurich ETH, Hönggerberg, CH-8093 Zürich, Switzerland |
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| Abstract: | β-Polypeptides are known to adopt helical secondary structure in organic solvents, even for rather short chain lengths. It is investigated whether a short α-polypeptide with amino-acid side chains that enable β-peptides to adopt helical structures, can maintain or adopt stable helical structure in methanol or in water. The molecular dynamics simulations do not predict a particular fold, which indicates an essential role for the additional methylene moiety in the backbone of β-peptides regarding helix stability. |
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| Keywords: | Alpha-peptide Beta-peptide Molecular dynamics simulation Peptide folding Conformation analysis |
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