Development of a new class of (1S,3R,4R)-2-azabicyclo[2.2.1]heptane-oxazoline ligands and their application in asymmetric transfer hydrogenation |
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| Authors: | Anna Trifonova |
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| Institution: | Department of Organic Chemistry, Institute of Chemistry, Uppsala University, Box 599, SE-75124 Uppsala, Sweden |
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| Abstract: | New 2-aza-norbornane-oxazoline compounds were synthesized and evaluated as ligands in the transfer hydrogenation of acetophenone. The best catalyst prepared in situ from IrCl2(COD)]2 and a ligand afforded 1-(S)-phenylethanol in good yields and 79% ee. |
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| Keywords: | Azabicyclo[2 2 1]heptane Oxazoline Chiral ligands [IrCl2(COD)]2 Acetophenone Catalysis Asymmetric transfer hydrogenation |
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