|
|||||
|
|
Synthesis of a PNA-encoded cysteine protease inhibitor library |
|
| Authors: | François Debaene Jennifer L Harris Nicolas Winssinger |
| Institution: | a Institut de Science et Ingénierie Supramoleculaires, Université Louis Pasteur, 8 allée Gaspard Monge, 67000 Strasbourg, France b Department of Chemistry, Genomics Institute of the Novartis Research Foundation, 10675 J. J. Hopkins Dr., San Diego, CA 92121, USA c Department of Molecular Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA |
| Abstract: | Peptide nucleic acids (PNAs) have been used to encode a combinatorial library whereby each compound is labeled with a PNA tag which reflects its synthetic history and localizes the compound upon hybridization to an oligonucleotide array. We report herein the full synthetic details for a 4000 member PNA-encoded library targeted towards cysteine protease. |
| Keywords: | Microarrays Combinatorial chemistry Protease inhibitors Peptide nucleic acid |
| 本文献已被 ScienceDirect 等数据库收录！ | |