Four new dimeric triterpene glucosides from Sanguisorba officinalis |
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Authors: | Xin Liu |
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Affiliation: | State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, People's Republic of China |
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Abstract: | In search for bioactive compounds from the roots of Sanguisorba officinalis L. (Rosaceae), four new dimeric triterpene glucosides, namely sanguidioside A, B, C, and D (1-4) were isolated. Alkaline hydrolysis of 1-2 afforded the corresponding dimeric aglycones (1a and 2a). Meanwhile, a ready intra-molecular transesterification was observed, providing dimeric triterpenes 1b and 2b. Alkaline hydrolysis of the crude dimmeric saponin also provided a new dimeric triterpene, sanguidiogenin (9). The structures of all these compounds are elucidated via spectroscopic and chemical methods, and are further confirmed by the X-ray diffraction analysis of the dimeric aglycone 2a. Compound 3 represents the first dimeric saponin of an oleanolic acid and an ursonic acid derivative, while compound 4 is the first dimeric saponin of oleanolic acid derivatives. |
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Keywords: | Sanguisorba officinalis Rosaceae Dimeric saponins Intra-molecular transesterification X-ray diffraction |
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