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Novel antifungal polyene amides from the myxobacterium Cystobacter fuscus: isolation, antifungal activity and absolute structure determination |
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| Authors: | Bangi A Kundim Youji Sakagami Shigeru Yamanaka |
| Institution: | a Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan b Institute of Life Science, Ajinomoto Co. Inc., Kawasaki-ku, Kawasaki 210-0801, Japan c Faculty of Textile Science and Technology, Shinshu University, Tokida, Ueda 386-8567, Japan |
| Abstract: | Three new unstable metabolites, (6E,10Z)-2′-O-methylmyxalamide D (1), 2′-O-methylmyxalamide D (2) and (6E)-2′-O-methylmyxalamide D (3) were isolated from the myxobacterium Cystobacter fuscus. The planar structures were elucidated by spectroscopic analyses to be geometrical isomers of a polyene amide related to a myxobacterial metabolite, myxalamide D (4). Their absolute stereochemistry was determined by synthesis of degradation products. Antifungal activities of 1-3 as well as their acetates were evaluated against the phythopathogenic fungus Phythopthora capsici. |
| Keywords: | Myxobacteria Cystobacter fuscus Antifungal Polyene antibiotics |
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