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Protein recognition using synthetic surface-targeted agents
Authors:Rishi Jain  Justin T. Ernst  Olaf Kutzki  Hyung Soon Park  Andrew D. Hamilton
Affiliation:Department of Chemistry, Yale University, New Haven, CT, USA.
Abstract:The design of synthetic agents to disrupt protein-protein interactions has received relatively little attention in recent years. In this review we describe strategies for targeting different types of protein surfaces using mimetics of protein secondary or tertiary structure. In this way strong and selective binding to a protein surface has be achieved and disruption of clinically important protein-protein interactions has been demonstrated in models of human disease.
Keywords:molecular recognition  protein-protein interactions
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