Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton |
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| Authors: | Nakano Chiaki Okamura Tomoo Sato Tsutomu Dairi Tohru Hoshino Tsutomu |
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| Institution: | Department of Applied Biological Chemistry, Faculty of Agriculture, and Graduate School of Science and Technology, Niigata University, Ikarashi, Niigata, 950-2181, Japan. |
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| Abstract: | The cloning and functional expression of Mycobacterium tuberculosis Rv3377c in Escherichia coli revealed that this gene encodes the diterpene cyclase for producing (+)-5(6),13-halimadiene-15-ol, which accepts geranylgeranyldiphosphate as the intrinsic substrate. |
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