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-trifluoroacylation - a convenient route to carboxylic acids |
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| Authors: | R.K. Mackie S. Mhatre J.M. Tedder |
| Abstract: | Trifluoroacetic anhydride will trifluoroacylate reactive aromatic and heterocylic nuclei without the aid of a Friedel-Crafts catalyst. The resulting trifluoromethyl ketone undergoes hydrolysis to yield the corresponding carboxylic acid. This provides a very simple route to aromatic and heterocyclic carboxylic acids. |
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