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Asymmetric hydrogenation of enamides with catalysts containing chiral thiourea ligands |
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| Authors: | M Lorraine Tommasino Magali Casalta Jrmy A J Breuzard Marc Lemaire |
| Institution: | Laboratoire de Catalyse et Synthèse Organique, CNRS: UMR 5622, CPE, Bât. 308, 43 bd. du 11 novembre 1918, 69622 Villeurbanne, France |
| Abstract: | The asymmetric reduction of enamides with molecular hydrogen and catalytic amounts of rhodium, iridium or ruthenium complexes containing chiral N,S-ligands is reported. Various enantiomerically pure mono- and dithioureas were examined. The C2-symmetry of the dithiourea ligands seems essential to the enantioselectivity achieved. Ee values of up to 70% were observed. |
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