Chemistry of renieramycins. Part 11: Total synthesis of (±)-cribrostatin 4 |
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Authors: | Masashi YokoyaHiroshi Ito Naoki Saito |
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Institution: | Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan |
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Abstract: | A 19-step synthesis of (±)-cribrostatin 4 (1) from readily available piperazine-2,5-dione derivative 6 is described. The synthesis features the concise construction of a pentacyclic framework, followed by the base-catalyzed epimerization of the C-1 stereo center of aldehyde (11). The results of cytotoxicity studies are also presented. |
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Keywords: | Total synthesis Marine natural product Isoquinoline Cribrostatin 4 Cytotoxicity |
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