Determination of atenolol in environmental water samples and pharmaceutical formulations at a graphite-epoxy composite electrode |
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Authors: | Carolina M.F. Calixto Priscila Cervini |
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Affiliation: | Instituto de Química de S?o Carlos, Universidade de S?o Paulo , Av. Trabalhador S?o-carlense, 400, CEP 13566-590, S?o Carlos , SP , Brazil |
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Abstract: | A bare graphite-epoxy composite was evaluated as an electrode material in the determination of atenolol in natural water samples and pharmaceutical formulations for which the analyte was spiked. Using a DPV procedure, a linear response was observed in the 4.45–84.7?µmol?L?1 range with a LOD?=?2.23?µmol?L?1, without need of surface renewal between successive runs, and recoveries between 92.5 and 107.5% for pharmaceutical formulations. The results obtained from the proposed procedure agreed with HPLC results within a 95% confidence level. During the determination of atenolol in water samples, recoveries between 96.1 and 102.6% were found. |
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Keywords: | atenolol graphite-epoxy composite electrode DPV |
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