Catalytic generation of activated carboxylates: direct, stereoselective synthesis of beta-hydroxyesters from epoxyaldehydes |
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Authors: | Chow Kenneth Yu-Kin Bode Jeffrey W |
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Institution: | Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106-9510, USA. |
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Abstract: | The catalytic generation of activated carboxylates from epoxyaldehydes enables the direct, stereoselective synthesis of beta-hydroxyesters under mild, convenient reaction conditions. In addition to providing a new method for the synthesis of anti-aldol adducts, this chemistry unveils a mechanistically viable solution to the catalytic, waste-free synthesis of esters. |
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