Effect of sulfur-containing amino acids and peptides on the free-radical fragmentation of biologically active phospho derivatives of glycerol |
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Authors: | E N Shendikova I V Mel’sitova I L Yurkova |
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Institution: | 1.Research Institute of Physicochemical Problems,Belarussian State University,Minsk,Belarus;2.Belarussian State University,Minsk,Belarus |
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Abstract: | The effects of sulfur-containing amino acids and peptides (cysteine, N-acetylcysteine (NAC), methionine, methionine sulfoxide (MetO), taurine (Tau), glutathione (GSH, GSSH), cysteinylglycine, and glutamylcysteine) on the free-radical degradation of glycero-1-phosphate and dimiristoyl phosphatidylglycerol with phosphoether bond rupture induced by γ-radiation or the Fe2+(EDTA)(Cu2+)–H2O2–(ascorbate) systems have been studied. In the case of a radiation-initiated process, thiols exert the greatest radioprotective effect in a concentration-dependent manner, and the action of MetO and Tau is neutral. In the case of Cu2+- mediated fragmentation, all of the test compounds with exception of Tau and NAC inhibit the process. The action of the test compounds on the fragmentation mediated by the Fe2+/EDTA–H2O2 (Fe2+–H2O2–ascorbate) systems can be either anti(pro)oxidant or neutral. In this case, all of the thiols other than glutamylcysteine exert an activating effect. |
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